Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

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Numerous people look for a “cannabis store near me” to buy marijuana, whether for alleviating their condition or simply for leisure. It’s widely recognized that cannabis products may assist in alleviating symptoms such as anxiety, depression, pain, nausea, and vomiting. Have you ever thought about its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids in the plant interact with the endocannabinoid system in the GI tract.
• Cannabis and pain medications can aid in managing Irritable Bowel Syndrome symptoms.
• cannabis serves various purposes, but most individuals recognize it for recreational and medical uses.

Gastrointestinal Disorders and cannabis Plant

The dietary impacts of nutraceuticals on gastrointestinal (GI) health are well-established. Certain diets have the potential to prevent or alleviate various GI conditions. Researchers have identified and evaluated the food components responsible for these effects.

Among the plant-based nutraceuticals that may benefit GI disorders are those derived from cannabis. cannabis refers to preparations sourced from the cannabis Sativa plant, a fragrant annual flowering herb.

John M. McPartland concluded in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. The cannabis genus, sativa, consists of three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis sativa serves various functions, including fiber production, oil extraction from seeds, and primarily, recreational or medicinal applications.

The Impact of the Plant

Receptors and ligands of the endocannabinoid system are distributed throughout various areas and systems, both within and outside the GI tract, which are relevant to the regulation of GI functions. Due to the presence of cannabinoid receptors, cannabinoids, including non-psychoactive phytocannabinoids, assist in modulating GI functions in health and disease conditions. The ECS is involved in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has many contributing factors, affecting 10–20% of individuals in developed nations. It presents as functional gastrointestinal disturbances without identifiable organic causes.

The enhancement of the antinociceptive properties of cannabinoids amid inflammation highlights the importance of the ECS in the development of visceral hypersensitivity. This finding not only illuminates the mechanisms behind conditions like IBS and other gastrointestinal disorders but also suggests promising therapeutic options for relieving abdominal and visceral pain.

Cannabinoids alone may not provide substantial relief for visceral hypersensitivity in IBS patients. Investigating combinations with other pain-modulating agents, such as opioids, offers an intriguing alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition of the GI tract resulting from environmental, genetic, and epigenetic factors.

Cannabidiol exhibits significant anti-inflammatory effects across various models of intestinal inflammation in mice and rats, as noted in a study in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease indicators:

• Reduction of structural damage
• Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal reported that the primary finding was the challenging tolerability of the botanical extract, with 90% of patients experiencing treatment-related adverse effects compared to 48% receiving the placebo.

A trend emerged toward improved quality of life scores and a positive change in patients’ overall impression, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract could offer therapeutic benefits to those who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, including colorectal cancer (CRC), rank among the most frequently diagnosed conditions in the general population.

Numerous studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, enhance endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

The confirmation of CBD’s chemopreventive properties emerged from examining in vivo models focusing on AOM-induced colon cancer. A dosage of 1 mg/kg resulted in a significant reduction: ACF decreased by 67%, while the number of tumors and polyps fell by 66% and 57%, respectively. Increasing the concentration to 5 mg/kg primarily showed efficacy in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive effects of CBD are observed when combined with THC, as indicated in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may result from the indirect stimulation of somatodendritic 5-HT1A receptors located in the dorsal raphe nucleus. This activation of autoreceptors may lead to reduced release of 5-HT in specific forebrain regions.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids inhibit transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, according to a study from the Journal of cannabis and Cannabinoid Research. These findings are significant as transient LES relaxations are the primary mechanism behind gastroesophageal reflux disease.

Cannabis Sativa for GI Issues

Conclusion

Multiple studies indicate that the advantages of cannabinoids extend not only to the well-known psychoactive compound THC but also to non-psychoactive molecules like CBD and others, which have received comparatively less attention. The cannabis plant impacts the GI system by interacting with the ECS to trigger various functions that can aid in managing symptoms of certain GI conditions.

Frequently Asked Questions

What can you expect when buying from online cannabis stores?

1. Accessing your cannabis products in Canada from an online store provides many options featuring both classic favorites and new products.
2. You can expect additional benefits like special offers, secure payment methods, and shipping options covering most provinces.
3. Essential resources, such as a blog section or contact page, are available to offer customers insights or assistance during their shopping experience.
4. As part of the purchase process, you’ll need to verify your age by presenting identification.
5. Some stores include taxes in their product prices, while others calculate it during checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two primary forms of measurement: metric and imperial units. On a cannabis site, you’ll find measurements in grams or ounces, allowing you to purchase products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis come from the same plant species, yet their differing effects and intended uses distinguish them. Medical cannabis acts as a therapeutic aid for specific health conditions, with a higher CBD composition compared to its recreational counterpart.

Are there ready-made joints available in a cannabis store?

Yes. These are in the form of pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient options for those who prefer their cannabis ready to use. There is a growing trend in the popularity of pre-rolled joints infused with cannabis concentrates.

Do cannabis online stores have a physical shop?

Not all online stores have physical locations, allowing you to have your purchases delivered directly to your home instead of picking them up from a physical store after placing an order online.

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