Emotionally Unstable Personality Disorder (EUPD), commonly referred to as Borderline Personality Disorder (BPD), significantly impacts social interactions, emotional regulation, and can result in impulsivity or self-harming tendencies. Treatment options can be expensive, with success rates varying from 35% to 50%. Researchers are currently investigating alternative therapies to enhance traditional treatment methods.
A noteworthy addition to EUPD treatment is the incorporation of cannabis, often called weed. It is budget-friendly, and its components may provide advantages for EUPD patients. Individuals facing financial constraints may seek out cheap cannabis online offers for more affordable solutions.
Table of Contents
Key Takeaways:
- Patients with EUPD utilizing THC or high CBD have shown positive outcomes in symptom management.
- Elevated doses of CBD (800 mg/day) and THC flower treatment can enhance circulating levels of anandamide.
- Impairments in the endocannabinoid system, responsible for emotional and stress regulation, are linked to Emotionally Unstable Personality Disorder.
Understanding EUPD or BPD
EUPD is a mental health disorder that influences self-perception and interpersonal relationships, leading to challenges in everyday functioning. It is characterized by intense, unstable relationships, impulsivity, and a distorted self-image.
While the exact origins of EUPD remain unclear, factors such as genetics, trauma, and neurotransmitter imbalances may contribute. Disruptions in the endocannabinoid system, which manages emotion and stress, may also play a role in EUPD symptoms.
EUPD Treatment
Despite guidelines indicating that no specific drugs are effective for EUPD, healthcare professionals frequently prescribe medications including antipsychotics and antidepressants.
Antipsychotic and sedative medications can sometimes assist in short-term crisis situations or in managing co-occurring conditions. A high percentage of EUPD patients—up to 90% in some studies—are prescribed at least one psychotropic medication, such as antipsychotics, antidepressants, mood stabilizers, and sedatives.
Polypharmacy is prevalent among these individuals, and many of these drugs are associated with side effects and are often used off-label for EUPD. While certain medications may alleviate specific symptoms, they typically do not alter the overall prognosis of the disorder.
Cannabis-Based Medicine for EUPD (CBM)
Cannabis-based medicines derive from the cannabis plant and contain cannabinoids, the active compounds in the plant, such as tetrahydrocannabinol (THC) and cannabidiol (CBD). These medicines are utilized to address various medical conditions and symptoms, including pain, inflammation, anxiety, seizures, and more.
Numerous studies are currently examining the effects on mental health. For instance, research published in Frontiers in Psychiatry suggests that marijuana may alleviate depression and improve sleep quality and overall well-being. These findings provide compelling reasons for further investigation into the impact of marijuana on different mental health disorders.
CBM for Unstable Personality Disorder
A narrative review and case series study in 2022 showcased the use of cannabinoids in managing EUPD symptoms among seven patients. The researchers examined the cellular and molecular mechanisms and assessed current evidence for cannabis-based medicinal products (CBMP) as potential treatments for EUPD.
Materials and Methods
| Participants | Diagnosed with EUPD who had attempted at least one medication and one form of psychotherapyAt least one follow-up review at a Zerenia clinic, with patient-reported outcome measures (PROMS) records. |
| CBM Used | Dried Flower for inhalation (20-60g per month) or Oral Extracts with THC (9-10mg/day) and CBD (40mg/day).Formulation: Chemotype 1: High THC, low CBD. Chemotype 2: Balanced THC and CBD. Chemotype 3: High CBD, low THC. |
| Measurement | Clinical Global Impression Improvement (CGI-I) Scale: A 1-7 scale where 1 indicates “very much improved” and 7 indicates “very much worse.”Patient’s Global Impression of Change (PGIC) Scale: A 1-7 scale where 1 represents “no change or worse” and 7 signifies “a great deal better and a considerable improvement.” |
Researchers personalized dosing through slow titration and provided guidelines for increasing the dose until satisfactory symptom control was achieved or side effects were noted.
Results
At a one-month follow-up, six participants reported improvements, with five rating their change as a six on the PGIC scale. Only one patient, who received a chemotype 2 oral extract, reported no benefit, suggesting that inhaled tetrahydrocannabinol or higher oral cannabidiol doses may be more effective.
All participants tolerated the treatment well, with no side effects reported, which is crucial for adherence. Younger patients may find medical cannabis more acceptable despite societal stigma.
Hypothesis
Researchers propose that exogenous cannabinoids may aid in restoring the tonic activation of the endocannabinoid system (ECS) in the central nervous system (CNS). THC directly activates presynaptic CB1 receptors, and both cannabinoids bind to fatty-acid binding proteins (FABPs), potentially slowing down the deactivation of anandamide.
High doses of oral cannabidiol (800 mg/day) and patients treated with chemotype 1 flower exhibit elevated levels of anandamide in circulation. It remains uncertain whether this is due to cannabidiol’s influence on anandamide transport or degradation or if it interacts with other molecular targets. In contrast, psychiatric medications typically require 2-3 weeks for initial effects and longer for remission.
The rapid symptom relief can be critical during an “EUPD crisis,” when distressed patients may resort to benzodiazepines and other anxiety medications. However, these substances can lead to quick tolerance and dependence.
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Frequently Asked Questions
Does cheap marijuana have poor quality?
No, price alone is not an indicator of product quality. Quality can be assessed by examining the product’s physical characteristics and personal experience. Some dispensaries may offer lower prices through monthly or clearance sales. If a dispensary’s prices fall below the industry standard, it may raise quality concerns.
Does marijuana cause any adverse effects when managing BPD?
No adverse side effects were reported by participants in the study. This is significant for medication adherence, as a review of 36 studies indicated that side effects accounted for 28% of patients’ non-adherence to antipsychotics. A negative perception of antipsychotic medication was the second most common reason for intentional non-adherence, at 30.5%.
What is the quickest way to experience the effects of cannabinoids for an EUPD problem?
Smoking, vaping, and dabbing are the quickest methods to experience the effects of cannabinoids. In the study, participants used vaping to consume dried flower. While smoking and vaping yield similar effects, the difference lies in inhaling smoke (from smoking) versus vapor (from vaping). Dabbing, which involves using concentrates, also ensures rapid onset of effects.
How many times can I smoke or vape to manage my symptoms?
The effectiveness of cannabis strains and products depends on individual responses. In the study, researchers allowed patients to adjust their daily dose (between 0.5 and 2 grams per day) as long as they did not exceed the monthly limit. For extracts, patients recorded their daily dosage.
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